Laboratorio del Doctor Elizondo

• Emmanuel González-Barbosa, Rosario García-Aguilar, Libia Vega, María Asunción Cabañas-Cortés, Frank J. Gonzalez, José Segovia, Sara L. Morales-Lázaro, Bulmaro Cisneros and Guillermo Elizondo.Parkin is Transcriptionally Regulated by the Aryl Hydrocarbon Receptor: Impact on α-Synuclein Protein Levels. Biochemical Pharmacology. 2019. 168:429-437.

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• Ana B. Villaseñor–Altamirano, John D. Watson, Stephenie D. Prokopec, Cindy Q. Yao, Paul C. Boutros, Raimo Pohjanvirta, Jesús Valdés-Flores and Guillermo Elizondo. 2,3,7,8-Tetrachlorodibenzo-p-dioxin modifies alternative splicing in mouse liver. Plos One. 2019. 14 (8): e0219747.

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• Omar Domínguez-Acosta, Libia Vega, Elizabet Estrada-Muñiz, Manuel S. Rodríguez,Frank J. Gonzalez and Guillermo Elizondo.Activation of aryl hydrocarbon receptor regulates the LPS/IFNg-induced inflammatory response by inducing ubiquitin-proteosomal and lysosomal degradation of RelA/p65. Biochemical Pharmacology. 2018. 155:141-149.

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• Alegre Flores-Pérez and Guillermo Elizondo.Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent. Chem-Biol Interact. 2018. 281:98-105.

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• Emmanuel González-Barbosa, Alejandro Mejía-García, Elizabeth Bautista, Frank J. Gonzalez, José Segovia, and Guillermo Elizondo. TCDD induces UbcH7 expression and synphilin-1 protein degradation in the mouse ventral midbrain. Journal of Biochemical and Molecular Toxicology. 31 (10). e21947.

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• Carmen Martínez-Guzmán, Pedro Cortés-Reynosa, Eduardo Pérez-Salazar, and Guillermo Elizondo. Dexamethasone Induces Human Glutathione S Transferase Alpha 1 (hGSTA1) Expression through the Activation of Glucocorticoid Receptor (hGR). Toxicology. 2017. 385. 59-66.

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• Medina-Díaz, I.M., Ponce-Ruiz, N., Ramírez-Chávez, B., Rojas-García, A.E., Barrón-Vivanco B.S., Elizondo, G., and Bernal-Hernández, Y. Downregulation of human paraoxonase 1 (PON1) by organophosphate pesticides in HepG2 cells. Environmental Toxicology. 2017. 32(2):490-500.

 

• Ángeles-Floriano T, Roa-Espitia AL, Baltiérrez-Hoyos R, Cordero-Martínez J, Elizondo G and Hernández-González EO. Absence of aryl hydrocarbon receptor alters CDC42 expression and prevents actin polymerization during capacitation. Molecular Reproduction and Development. 2016. 83 (11): 1015-1026.

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• Samantha Climaco-Arvizu, Omar Domínguez-Acosta, María Asunción Cabañas-Cortés, Miriam Rodríguez-Sosa, Frank J. Gonzalez, Libia Vega, and Guillermo Elizondo. Aryl hydrocarbon receptor influences nitric oxide and arginine production and alters M1/M2 macrophage polarization. Life Sciences. 2016. 155:76-84

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• Ponce-Ruiz, N., Rojas-García, A.E., Barrón-Vivanco B.S., Elizondo, G., Bernal-Hernández, Y.Y., Mejía-García, A., Medina-Díaz, I.M. Transcripcional regulation of human paraoxonase 1 by PXR and GR in human hepatoma cells. Toxicology in vitro. 2015. 30: 348-354.

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• Alejandro Mejía-García, Emmanuel González-Barbosa, Carmen Martínez-Guzmán, Mónica Torres-Ramos, Manuel Rodríguez, Simón Guzmán-León, and Guillermo Elizondo. Activation of AHR mediates the ubiquitination and proteasome degradation of c-Fos through the induction of Ubcm4 gene expression. Toxicology. 2015. 337. 47-57

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• Lucia García-Lara, Francisca Pérez-Severiano, Dinora González-Esquivel, Guillermo Elizondo, José Segovia. The absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress. J. Neurosience Research. 2015. 93 (9). 1423-33.

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• David Alam-Escamilla, Elizabet Estrada-Muñiz, Erik Solís Villegas, Guillermo Elizondo, and Libia Vega. Genotoxic and Cytostatic Effects of 6-Pentadecyl Salicylic Anacardic Acid in Tumour Cell Lines and Peripheral Blood Mononuclear Cells. Mutation Res. 2015. 777. 43-53.

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• Octavio D. Reyes-Hernández, Libia Vega, Miguel A. Jiménez-Ríos, Pedro F. Martínez-Cervera, Juan A. Lugo-García, Leticia Hernández-Cadena, Patricia Ostrosky-Wegman, Lorena Orozco and Guillermo Elizondo. The PXR rs7643645 polymorphism is associated with the risk of higher prostate-specific antigen levels in prostate cancer patients. Plos One. 2014. 6, e99974.

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• Libia Vega and Guillermo Elizondo. Aryl  hydrocar receptor as a new therapeutic target for cancer and immune disorders. World Journal of Pharmacology. 2013. 2 (4). 107-114.

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• Mejía-García, A., Sánchez-Ocampo, E. M., Galindo Gómez, S., Shibayama, M., Reyes-Hernández, O. D. Guzmán-León S., Gonzalez, F.J., and Elizondo, G. 2,3,7,8-Tetrachlorodibenzo-p-dioxin enhances CCl4-induced hepatotoxicity in an aryl hydrocarbon receptor-dependent manner.  Xenobiotica. 2013. 43. 161-168.

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• Briscia S. Barrón-Vivanco, Stephen J. Rothenberg, Irma M. Medina-Díaz, Lourdes Robledo-Marenco, Aurora E. Rojas-García,Leticia Hernández-Cadena, Guillermo Elizondo and Arnulfo Albores. AKRs expression in peripheral blood lymphocytes from smokers: The role of body mass index. Human and Experimental Toxicology. 2013. 32 (4). 418-426.

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• Sihomara García-Zepeda, Elizabet Estrada-Muñiz, Guillermo Elizondo, Luis I. Terrazas, Miriam Rodríguez-Sosa, Juan D. Quintana-Hau, Rubén Tornero-Montaño, Leopoldo Baiza-Durán and Libia Vega. Levocetirizine inhibits migration of immune cells to lymph nodes and induces Treg cells in a murine type I allergic conjunctivitis model. The Open Ophthalmology Journal. 2012. 6: 136-143.

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• Pilar García-Roca, Mara Medeiros, Herlinda Reyes, Benjamín Rodríguez-Espino, Josefina Alberú, Lourdes Ortiz, Mayela Vásques-Perdomo, Guillermo Elizondo-Azuela, Luis Eduardo Morales-Buenrostro, Eduardo Mancilla Urrea, Gilberto Castañeda-Hernández. Cyp3A5 gene polymorphsim in mexican renal transplant recipients and its association with tacrolimus dosing. Arch. Med. Research. 2012. 43 (4): 283-287.

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• I. M. Medina-Díaz, M. Rubio-Ortíz, M.C. Martínez-Guzmán, R.L. Dávalos-Ibarra, A.E. Rojas-García, M.L. Robledo Marenco, B.S. Barrón-Vivanco, M.I. Girón-Pérez,  G. Elizondo. Organophosphate pesticides increase the expression of alpha glutathione 5-transferase in HepG2 cells. Toxicology in Vitro 2011. 25: 2074-2079.

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• Guillermo Elizondo, Miriam Rodríguez-Sosa, Elizabet Estrada-Muñiz, Frank J. Gonzalez and Libia Vega. Dletion of the Aryl HydrocarbonReceptor Enhances the Inflammatory Response to Leishmania major Infection. Int. J. Biol. Sci, 2011, 7 (9): 1220-1229.

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• Reyes-Hernández, O. D., Mejía-García, A, Sánchez-Ocampo, E. M , Cabañas-Cortés, M.A., Ramírez, P., Chávez-González, L, Gonzalez, F.J., and Elizondo, G. Ube2l3 gene expression is modulated by activation of the aryl hydrocarbon receptor: Implications for p53 ubiquitination. Biochem. Pharmacol. 2010. 80: 932-940.

 

• Olvera-Bello AE, Estrada-Muñiz E, Elizondo G, Vega L. Susceptibility to the cytogenetic effects of dichloromethane is related to the glutathione S-transferase theta phenotype. Toxicol Lett. 2010. 199 (3): 218-24.

 

• Libia Vega, Yuriko Sanchez, Juan de Dios Rosado, Guillermo Elizondo, Rafael Saavedra, Imelda Juárez, and Miriam Rodríguez-Sosa. The unexpected role for the aryl hydrocarbon receptor on susceptibility to experimental toxoplasmosis. Journal of Biomedicine and Biotechnology. J.Biomed.Biotechnol. 2010. 2010:505694

 

• Reyes-Hernández, O.D., Mejía-García, A., Sánchez-Ocampo E.M., Castro-Muñozledo, F., Hernández-Muñoz, R., and Elizondo, G. Aromatic hydrocarbons upregulate glyceraldehyde-3-phosphate dehydrogenase and induce changes in actin cytoskeleton. Role of the aryl hydrocarbon receptor (AhR). Toxicology. 2009. 266:30-37.

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• Vega L,  Leyva JF, López MC, Valverde M, Elizondo G, Rojas E. Diethylthiophosphate and Diethyldithiophosphate Induce Genotoxicity in Hepatic Cell Lines When Activated by Further Biotransformation Via Cytochrome p450. Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 2009. 679: 39-43.

 

• Medina-Díaz  I.M., Estrada-Muñiz E., Reyes-Hernández O.D, Ramírez P., Vega L., and Elizondo G. Arsenite and its Metabolites, MMAIII and DMAIII, Modify CYP3A4, PXR and RXR alpha Expression in the Small Intestine of CYP3A4 Transgenic Mice. Toxicol. Appl. Pharmacol. 2009. 239(2):162-168.

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• Guillermo Elizondo, Irma M. Medina-Díaz, Raymundo Cruz, Frank J. Gonzalez, and Libia Vega. Retinoic Acid modulatesRaldh1 gene expression through the induction of GADD153-C/EBPb interaction. Biochem. Pharmacol. 2009. 77: 248-257.

 

• Victor Olvera-García, Eduardo Castaño-Tostado, R. Reynoso-Camacho, Elvira González de Mejía, Guillermo Elizondo-Azuela,  Guadalupe Loarca-Piña. Hibiscus sabdariffa. L. Extracts Inhibit the Mutagenicity in Microsuspension Assay and the Proliferation of HeLa Cell . Journal of Food Science. 2008. 73: 75-81.

 

•  Xochitl Aparicio-Fernández, Rosalia Reynoso-Camacho, Eduardo Castaño-Tostado, Teresa García-Gasca, Elvira González de Mejía, S. Horacio Guzmán-Maldonado, Guillermo Elizondo, Gad Gabra Yousef, Mary Ann Lila, Guadalupe Loarca-Pina. Antiradical capacity and induction of apoptosis in HeLa cells by a Phaseolus vulgaris extract. Plants Foods for Human Nutrition. 2008. 63: 35-40.

 

• Octavio D. Reyes-Hernández, Ismael Lares-Asseff, Martha Sosa-Macías. Libia Vega, Arnulfo Albores and Guillermo Elizondo.A comparative study of CYP3A4 polimorphisms in a Mexican Amerindian and Mestizo populations. Pharmacology. 2008. 81: 92-96.

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• R. Villalobos-Molina, F.G. Vázquez-Cuevas, J.J.López-Guerrero, M.C. Figueroa-García, I.A. Gallardo-Ortiz, M. Ibarra, M. Rodríguez-Sosa, F.J. González, and G. Elizondo. Vascular α1D-Adrenoreceptors are overexpressed in aorta of the aryl hydrocarbon receptor null mouse: Role of increased angiotensin II. Autonomic and Autacoid Pharmacology. 2008. 28:61-67.

 

• Libia Vega, Miriam Rodríguez-Sosa, Eliud A. García-Montalvo, Luz María Del Razo, Guillermo Elizondo. Non-optimal levels of dietary selenomethionine alter splenocyte response and modify oxidative stress markers in female mice. Food and Chemical Toxicology. 2007. 45: 1147-53.

 

• Irma M. Medina-Díaz, Georgina Arteaga-Illán, Mario Bermúdez de León, Bulmaro Cisneros, Adolfo Sierra-Santoyo, Libia Vega, Frank J. González and Guillermo Elizondo. Pregnane X Receptor-dependent induction of the CYP3A4 gene by o,p´-DDT.  Drug Metabolism and Disposition. 2007. 35: 95-102.

 

• Guillermo Avila, Irma M. Medina, Esperanza Jiménez, Guillermo Elizondo, and Citlalli I. Aguilar. Transforming growth factor--β1 decreases cardiac muscle L-type Ca2+ current and charge movement by acting on the Cav 1.2 mRNA. Am.  J. Physiol Heart Circ Physiol. 2007. H622-H631.

 

• Mario Bermúdez-de-León, PhD; Pablo Gómez, B.S.; Guillermo Elizondo, PhD; Rocío Zatarain-Palacios, M.S.; Francisco Garcia-Sierra, PhD; Bulmaro Cisneros, PhD. ß-Naphthoflavone Represses Dystrophin Dp71 Expression in Hepa-1. Cells. BBA - Gene Structure and Expresión. Biochimica et Biophysica Acta. 2006. 1759: 152-158.

 

• Sosa-Macías M., Elizondo G., Flores-Pérez C., Flores-Pérez     J.Bradley-Alvarez F., Alanis-Bañuelos, Lares-Asseff I. CYP2D6 Genotype and Phenotype in Amerindians of Tepehuano Origin and Mestizos of Durango, Mexico. J. Clin. Pharmacol. 2006. 46:527-536.

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• Miriam Rodríguez-Sosa, Guillermo Elizondo, Rosa María López-Durán, Irma Rivera, Frank J. Gonzalez and Libia Vega. Over-Production of IFN-g and IL-12 in AhR-null mice. FEBS Letters 2005. 579 (28): 6403-6410.

 

• Irma M. Medina-Díaz y G. Elizondo. Transcriptional induction of CYP3A4 by o,p’-DDT in HepG2 cells. Tox. Lett. 2005. 157:41-47.

 

• Lares-Asseff I., Sosa-Macías M., Elizondo-Azuela G., Flores-Pérez C., Bradley-Alvarez F. Phenotypical expression of CYP2D6 in amerindiands of tepehuano origin from Durango, Mexico. Proc. West Pharmacol. Soc. 2005. 48:102-107.

 

• Reyes-Hernández O, Arteaga-Illán G, Elizondo G. Detection of CYP3A4*1B and CYP3A4*2 polymorphisms by RFLP. Distribution frequencies in a Mexican population. Clin. Genetics 2004, 66:166-168.

 

• Andreola F, Elizondo G, Jakowlew S, Calvisi D, Gonzalez FJ, De Luca LM. Reversal of Liver Fibrosis in Aryl Hydrocarbon Receptor Knockout Mice by Vitamin A Depletion. Hepatology 2004, 39 (1): 157-166.​

 

• Elizondo G, Medina-Díaz IM. Induction of CYP3A4 by 1alpha, 25-dyhydroxyvitamin D(3) in HepG2 cells. Life Sci 2003 May 30; 73(2):141-149.

 

• Granvil CP, Yu AM, Elizondo G, Akiyama TE, Cheung C, Feigenbaum L, Krausz KW, Gonzalez FJ. Expression of the Human CYP3A4 Gene in the Small Intestine of Transgenic Mice: In Vitro  Metabolism and Pharmacokinetics of Midazolam. Drug Metab Dispos 2003 May 31; (5):548-58.

 

• Menéndez D., Rojas E., Herrera L.A., Lopez M.C., Sordo M., Elizondo G. and Ostrosky-Wegman P. DNA breakage due to metronidazole treatment. Mutat Res. 2001 Jul 1;478(1-2):153-8.

 

•  Aitchison K.T., Gonzalez F.J., Quattrochi L.C., Sapone A., Zhao J.H., Zaher H., Elizondo G., Bryant C., Munro J., Collier D.A., Makoff A.J., and Kerwin R.W. Identification of novel polymorphism in the 5´flanking region of CYP1A2, characterization of interethnic variability, and investigation of their functional significance. Pharmacogenetics 10 (8), (2000): 695-704.

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• Elizondo G., Corchero J., Sterneck E. and Gonzalez F.J. Feedback inhibition of the Retinaldehyde Dehydrogenase gene ALDH1 by Retinoic Acid through Retinoic Acid receptor a and CCAAT/Enhancer-binding protein b. J.Biol.Chem. 275 (50), (2000): 39747-39753.

 

• Tohkin M., Fukuhara M., Elizondo G., Tomita S. and Gonzalez F.J. Aryl Hydrocarbon Receptor is required for p300-mediated induction of DNA synthesis by Adenovirus E1A. Mol.Pharmacol. 58 (4), (2000): 845-851.

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• Elizondo G., Fernandez-Salguero P, Saeed Sheikh M., Geum-Yi K., Fornace A.J., Lee K.S, Gonzalez F.J. Altered cell cycle control at the G2/M phases in aryl hydrocarbon receptor-null embryo fibroblast . Mol. Pharmacol. 57 (5), (2000): 1056-1063.

 

• Sata F; Sapone A; Elizondo G; Stocker P; Miller V.P; Zheng W; Hannu R; Crespi C.L. and Gonzalez F.J. CYP3A4 allelic variants with amino acid substitutions in exons 7 and 17: Evidence for an allelic variant with altered catalytic activity. Clinical Pharmacology and Therapeutics 67 (2000): 48-56.

 

• Peters J.M., Narotsky M.G., Elizondo G., Fernández-Salguero P.M., González F.J. and Abbott B.D. Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice. Toxicology Science 47 (1999): 86-92.

 

• Elizondo G., Xiaoxiong W., Sapone A., Fernández-Salguero P.M. and González F.J. Characterization of the human dihydropyrimidine dehydrogenase gene. Genomics 51 (1998): 391-400.

 

•  Elizondo G., Gonsebatt M.E., Salazar A.M., Lares I., Santiago P., Herrera J.E., Hong E. and Ostrosky-Wegman P. Genotoxic effects of metronizole. Mutation Research 307 (1996): 75-80.

 

• Elizondo G. and Ostrosky-Wegman P. Effects of metronidazole and its metabolites on histamine immunosuppression activity. Life Sciences 59(4) (1996): 285-297.

 

• Elizondo G., Montero R., Herrera J.E., Hong E. and Ostrosky-Wegman P. Lymphocyte proliferation kinetcis and sister chromatid exchanges in individuals treated with metronidazole. Mutation Research 305 (1994) 133-137.

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• Ostrosky-Wegman P., Lares A., Santiago P., Elizondo G. and Montero, R. Metronidazole hprt mutation induction in sheep and the relationship with its elimination rate. Mutation Research 307 (1994), 253-259.